Inside

Finding the Cures

James R. Downing, MD and Charles G.Mullighan, MBBS(Hons), MSc, MD
Scientists at St. Jude have identified distinctive genetic changes that cause relapse in children with acute lymphoblastic leukemia (ALL).
 

Basic Science

The diverse research at St. Jude ranges from discovery-focused and hypothesis-testing laboratory studies to clinical trials of specific agents, regimens, or therapeutic interventions. We continually seek to translate knowledge acquired through basic research into novel approaches for clinical diagnosis and treatment. At the same time, our clinical and laboratory-based investigators use the challenges encountered in the clinic to focus the efforts of our research.

The Research Behind the Cures

Douglas R. Green, PhD

New insight into the controls on a go-to enzyme

Scientists at St. Jude have gained new insights into regulation of one of the body’s enzyme workhorses called calpains.

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Scientific Report 2008

Scientific Report

Key research activities and publications by the investigators at St. Jude during 2007 are summarized in the Scientific Report 2008.

In the News

Mary-Ann Bjornsti, PhD
A team of scientists at St. Jude have gained new insight into the function of DNA topoisomerase 1 (Top1). This finding may yield a new approach to anti-cancer drugs that can jam the function of this enzyme and kill cancer cells.

Interactive / Multimedia